Is chronic traumatic encephalopathy a real disease?

Military-related traumatic brain injury and neurodegeneration

Mild traumatic brain injury (mTBI) includes concussion, subconcussion, and most exposures to explosive blast from improvised explosive devices. mTBI is the most common traumatic brain injury affecting military personnel; however, it is the most difficult to diagnose and the least well understood. It is also recognized that some mTBIs have persistent, and sometimes progressive, long-term debilit...

Pathology of Chronic Traumatic Encephalopathy (cte) Program Syllabus

The spectrum of disease in chronic traumatic encephalopathy.

Chronic traumatic encephalopathy is a progressive tauopathy that occurs as a consequence of repetitive mild traumatic brain injury. We analysed post-mortem brains obtained from a cohort of 85 subjects with histories of repetitive mild traumatic brain injury and found evidence of chronic traumatic encephalopathy in 68 subjects: all males, ranging in age from 17 to 98 years (mean 59.5 years), inc...

Tau-ism: The Yin and Yang of Microtubule Sliding, Detachment, and Rupture.

Traumatic brain injury is a nondegenerative, noncongenital insult to the brain caused by external mechanical forces. Recent studies suggest that even mild concussions—if repetitive—can trigger progressive neurological degeneration, a condition that is now widely known as ‘‘chronic traumatic encephalopathy’’ (1). Notably, chronic traumatic encephalopathy continues to progress even decades after ...

Spinal cord pathology in chronic traumatic encephalopathy with motor neuron disease

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